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Amitriptyline belongs to a family of medications known as tricyclic antidepressants. It works in the central nervous system (CNS) to elevate the mood of people with depression.

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It is believed to work by keeping the balance of natural chemicals (neurotransmitters) in the body, namely serotonin and norepinephrine.

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Many people living with chronic pain are daunted by the prospect of long term or even permanent drug therapy.

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Besides depression, amitriptyline can be used "off-label" to treat post-herpetic neuralgia (a condition that occurs after having shingles), attention deficit hyperactivity disorder (ADHD), and certain eating disorders.

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