Metformin and bilirubin

brittney473   05-Jan-2018 12:39   Комментариев к записи Metformin and bilirubin 4

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Understanding Urinalysis Clues for the

He served as president to the Colorado Association of Naturopathic Physicians and is on the board of directors of both the Oncology Association of Naturopathic Physicians and the American Association of Naturopathic Physicians.

Drug tables - Medication Tables - Drug

Course Content - #33400 Diabetes and

While family planning and preconception care are of utmost importance to women with pre-existing diabetes, blood glucose management is critical throughout the gestational period of all pregnancies complicated by diabetes.

Yellow Bowel Movement and Yellow

Initial 200-300 mg PO q4-6hr initially on Day 1 (may require 800-1200 mg/day), then reduce gradually; some practitioners propose an initial dose of 600-1000 mg with gradual dose reduction after initial response Maintenance: 100-150 mg/day PO divided q8-12hr Agranulocytosis Aplastic anemia Dermatologic reactions Hepatitis Polyarthritis Drowsiness Fever Headache Verto Alopecia Erythema nodosum Exfoliative dermatitis Skin rash Skin ulcers Goiter Weht gain Constipation Loss of taste Granulopenia Leukopenia Thrombocytopenia Inhibition of myelopoiesis (agranulocytosis, granulopenia, aplastic anemia, and thrombocytopenia) Drug fever, a lupus-like syndrome (including splenomegaly and vasculitis) Periarteritis Hypoprothrombinemia Bleeding Nephritis Glomerulonephritis Interstitial pneumonitis Exfoliative dermatitis Erythema nodosum Vasculitis syndrome associated with the presence of antineutrophilic cytoplasmic antibodies (ANCA) Skin rash Uticaria Nausea Vomiting Epastric distress Arthralgia Paresthesias Loss of taste Taste perversion Severe liver injury and acute liver failure, some of which have been fatal, have been reported in adult and pediatric patients taking propylthiouracil Closely monitor for symptoms and sns of liver injury (eg, , anorexia, nausea, vomiting, fatue, pruritus, dark colored urine, or jaundice), especially during first 6 months after initiating therapy Reserve propylthiouracil use for those unable to tolerate other treatments (eg, methimazole, radioactive iodine, surgery) Propylthiouracil may be the treatment of choice during and just before the first trimester of pregnancy (strong association of methimazole with congenital malformation during first trimester) Liver disease, bleeding disorder, pregnancy, concurrency with other agranulocytosis-causing drugs Risk of severe liver injury and rare immunoallergenic hepatitis Discontinue immediately if abnormal LFTs (transmainase 3 times ULN) Risk of rare but serious agranulocytosis may occur Bone marrow suppression reported Severe dermatologic reactions reported Discontinue in the presence of unexplained fever Lupus-like syndrome reported (may need to discontinue) Glomerulonephritis and interstitial nephritis with acute renal failure reported Interstitial pneumonitis and different forms of vasculitis may occur Hh relapse rate (more likely in smokers) May cause hypoprothrombinemia Propylthiouracil can cause hypothyroidism necessitating routine monitoring of TSH and free T4 levels with adjustments in dosing to maintain a euthyroid state; because drug readily crosses placental membranes, propylthiouracil can cause fetal goiter and cretinism when administered to a pregnant woman Patients should be instructed to report any symptoms of hepatic dysfunction (anorexia, pruritus, jaundice, lht colored stools, dark urine, rht upper quadrant pain, etc.), particularly in the first six months of therapy; when symptoms occur, measurement should be made of liver function (bilirubin, alkaline phosphatase) and hepatocellular integrity (ALT/AST levels) Absorption: 75% Duration: 12-24 hr Half-life elimination: 1-2 hr, increase in ESRD Vd: 0.4 L/kg Protein Bound: 80-85% Concentration (200-400 mg single dose): 6-9 mcg/m L Peak plasma time: 1-2 hr Peak plasma concentration: (200-400 mg single dose): 6-9 mcg/m L Metabolism: liver, to glucuronide conjugates, inorganic sulfates, sulfur metabolites Total body clearance: 7 L/hr Excretion: Urine (35%) The above information is provided for general informational and educational purposes only.


Metformin and bilirubin:

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