- Aciphex Rabeprazole Sodium Patient
- Aciphex Rabeprazole Sodium Drug Information. - RxList
- Aciphex oral Uses, Side Effects, Interactions, Pictures.
Aciphex Rabeprazole Sodium Patient
Indicated for short-term (up to 4 weeks) treatment in healing and symptomatic relief of duodenal ulcers 20 mg PO q Day after morning meal for up to 4 weeks; to achieve healing, some patients may require additional therapy In combination with amoxicillin and clarithromycin for treatment of H pylori infection and duodenal ulcer disease (active or history within past 5 yr) 20 mg PO BID for 7 days with morning and evening meals; take with amoxicillin 1000 mg PO BID and clarithromycin 500 mg BID Agitation Agranulocytosis Alopecia Anemia Angioedema Chest pain Delirium Erythema Hypokalemia Hypomagnesemia Hyponatremia Jaundice Leukocytosis Leukopenia Mraine Osteoporosis related fracture Rhabdomyolysis Stevens-Johnson syndrome Sudden death Toxic epidermal necrolysis Abnormal taste PPIs are possibly associated with increased incidence of Clostridium difficile-associated diarrhea (CDAD); consider diagnosis of CDAD for patients taking PPIs with diarrhea that does not improve Liver disease: May require dosage reduction Cutaneous lupus erythematosus (CLE) and systemic lupus erythematosus (SLE) reported with PPIs; avoid using for longer than mediy indicated; discontinue if sns or symptoms consistent with CLE or SLE are observed and refer patient to specialist Use of proton pump inhibitors may increase risk of salmonella and campylobacter infection Reduce of symptoms does not eliminate presence of gastric malnancy Published observational studies suggest that PPI therapy may be associated with an increased risk of osteoporosis-related fractures of the hip, wrist, or spine; particularly with prolonged (1 yr), hh-dose therapy Decreased gastric acidity increases serum chromogranin A (Cg A) levels and may cause false positive diagnostic results for neuroendocrine tumors; temporarily discontinue PPIs before assessing Cg A levels Hypomagnesemia may occur with prolonged use (ie, 1 yr); adverse effects, such as tetany, arrhythmias, or seizures, may result; in 25% of cases reviewed, magnesium supplementation alone did not improve low serum magnesium levels, and the PPI had to be discontinued Monitor for increases in INR and prothombin time when coadministered with warfarin Daily long-term use (e.g., longer than 3 years) may lead to malabsorption or a deficiency of cyanocobalamin Acute interstitial nephritis reported in patients taking proton pump inhibitors Concomitant use of proton pump inhibitors with methotrexate, primarily at hh dose, may elevate and prolong serum concentrations of methotrexate and/or its metabolite, possibly leading to methotrexate toxicities; in hh-dose methotrexate administration, a temporary withdrawal of the PPI may be considered in some patients Metabolism: Liver; extensively by hepatic P450 enzyme CYP2C19; second pathway through CYP3A4; also by non-enzymatic reduction Metabolites (presumed inactive): Rabeprazole thioether, sulfone metabolite, desmethyl metabolite, desmethyl thioether, thioether carboxylic acid CYP2C19 substrate (minor) The above information is provided for general informational and educational purposes only.
Aciphex Rabeprazole Sodium Drug Information. - RxList
Rabeprazole is used to treat certain stomach and esophagus problems (such as acid reflux, ulcers).
I take Aciphex daily to control bile reflux and no one ever told me to wait 4 hours after taking my synthroid.
Aciphex oral Uses, Side Effects, Interactions, Pictures.
Acip Hex is used short-term to treat symptoms of gastroesophageal reflux disease (GERD) in adults and children who are at least 1 year old.
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